![]() ![]() It is structurally related to psilocybin and psilocin, the active ingredient in psilocybin mushrooms ("magic mushrooms"). However, it was not tested for psychoactivity during this time.Ĥ-AcO-DMT is thought to produce its effects by binding to serotonin receptors in the brain however, the precise mechanism is not known.Ĥ-AcO-DMT was first synthesized in 1963 by Albert Hofmann and Franz Troxler as part of a chemical investigation into psilocin analogs. It is unknown when it was first explored in humans. Nichols in 1999 proposed its potential use as an alternative to psilocybin for pharmacological research due to the lower cost of synthesis. Reports of recreational use began to surface shortly after its appearance on the online research chemical market in the 2010s.
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